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Strain Registration

Strain: TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo

Symbol: TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo
Strain: TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)
Substrain: Nyo
RGD ID: 11041128
Citation ID: RRID:RGD_11041128
Ontology ID: RS:0004171
Alleles: Cblb
Also Known As: TM.KDP-Chr9,12,18 triple congenic; NBRP Rat No: 0807; TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: The Cblb mutation, one of the causative gene in type 1 diabetes of KDP/Tky and KDP alleles in other modifier genes were transferred onto the genetic background of TM:Kyo strain.
Coat Color: fawn hooded
Inbred Generations: N5F13
Last Known Status: Cryopreserved Sperm
Research Usage Diabetes Obesity






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat. Yokoi N, etal., Diabetes. 2007 Feb;56(2):506-12.
4. Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain. Yokoi N, etal., Exp Anim 2003 Jul;52(4):295-301.
5. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi N, etal., Nat Genet 2002 Aug;31(4):391-4.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Cblb homozygous rats show mild to severe insulitis. The incidence of Type 1 diabetes is 20 to 50% (The onset of Type 1 diabetes is later and the incidence is lower than those of KDP rat strain 1302502
strain_reproduction Maintained as segregating inbred strain (Cblb mutation: heterozygous). Homozygous Cblb rats are infertile in both sexes. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-24 TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo    TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo    Name updated 68913 APPROVED
2016-03-24 TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo    TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo    Name updated 68913 APPROVED